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| merck technology symposium 2023: Cell Culture Engineering Wei-Shu Hu, 2006-08-16 Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade. |
| merck technology symposium 2023: Proceedings of the Green Materials and Electronic Packaging Interconnect Technology Symposium Mohd Arif Anuar Mohd Salleh, Dewi Suriyani Che Halin, Kamrosni Abdul Razak, Mohd Izrul Izwan Ramli, 2023-07-02 This book presents peer reviewed articles from the Green Materials and Electronic Packaging Interconnect Technology Symposium, (EPITS 2022), held in Langkawi, Malaysia on 14th and 15th of Sept, 2022. It brings together packaging experts to share and exchange ideas in electronics technology. Topics covered in this volume include, but are not limited to; (1) Green materials and technology, (2) Emerging interconnect materials and technologies,(3) Non-solder interconnect materials at chip and package levels, (4) Fundamental materials behavior for electronic packaging materials, (5) Advanced characterization methods as applied to electronic packaging technology, (6) Developments in high temperature Pb-free solders and associated interconnects for automotive and power electronics, (7) Surface coating materials & (8) Advanced materials. |
| merck technology symposium 2023: Proceedings of the XVII International symposium Symorg 2020 Dušan Starčević, Sanja Marinković, 2020-06-30 Ever since 1989, the Faculty of Organizational Sciences, University of Belgrade, has been the host of SymOrg, an event that promotes scientific disciplines of organizing and managing a business. Traditionally, the Symposium has been an opportunity for its participants to share and exchange both academic and practical knowledge and experience in a pleasant and creative atmosphere. This time, however, due the challenging situation regarding the COVID-19 pandemic, we have decided that all the essential activities planned for the International Symposium SymOrg 2020 should be carried out online between the 7th and the 9th of September 2020. We are very pleased that the topic of SymOrg 2020, “Business and Artificial Intelligence”, attracted researchers from different institutions, both in Serbia and abroad. Why is artificial intelligence a disruptive technology? Simply because “it significantly alters the way consumers, industries, or businesses operate.” According to the European Commission document titled Artificial Intelligence for Europe 2018, AI is a key disruptive technology that has just begun to reshape the world. The Government of the Republic of Serbia has also recognized the importance of AI for the further development of its economy and society and has prepared an AI Development Strategy for the period between 2020 and 2025. The first step has already been made: the Science Fund of the Republic of Serbia, after a public call, has selected and financed twelve AI projects. This year, more than 200 scholars and practitioners authored and co-authored the 94 scientific and research papers that had been accepted for publication in the Proceedings. All the contributions to the Proceedings are classified into the following 11 sections: Information Systems and Technologies in the Era of Digital Transformation Smart Business Models and Processes Entrepreneurship, Innovation and Sustainable Development Smart Environment for Marketing and Communications Digital Human Resource Management Smart E-Business Quality 4.0 and International Standards Application of Artificial Intelligence in Project Management Digital and Lean Operations Management Transformation of Financial Services Methods and Applications of Data Science in Business and Society We are very grateful to our distinguished keynote speakers: Prof. Moshe Vardi, Rice University, USA, Prof. Blaž Zupan, University of Ljubljana, Slovenia, Prof. Vladan Devedžić, University of Belgrade, Serbia, Milica Đurić-Jovičić, PhD, Director, Science Fund of the Republic of Serbia, and Harri Ketamo, PhD, Founder & Chairman of HeadAI ltd., Finland. Also, special thanks to Prof. Dragan Vukmirović, University of Belgrade, Serbia and Prof. Zoran Ševarac, University of Belgrade, Serbia for organizing workshops in fields of Data Science and Machine Learning and to Prof. Rade Matić, Belgrade Business and Arts Academy of Applied Studies and Milan Dobrota, PhD, CEO at Agremo, Serbia, for their valuable contribution in presenting Serbian experiences in the field of AI. The Faculty of Organizational Sciences would to express its gratitude to the Ministry of Education, Science and Technological Development and all the individuals who have supported and contributed to the organization of the Symposium. We are particularly grateful to the contributors and reviewers who made this issue possible. But above all, we are especially thankful to the authors and presenters for making the SymOrg 2020 a success! |
| merck technology symposium 2023: Proceedings of the 2nd Lawang Sewu International Symposium on Health Sciences Gela Setya Ayu Putri, 2024 |
| merck technology symposium 2023: Cell Line Development Mohamed Al-Rubeai, 2009-08-11 Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This unique advantage outweighs the costs associated with mammalian cell culture, which are far grater in terms of development time and manufacturing when compared to microbial culture. The development of cell lines has undergone several advances over the years, essentially to meet the requirement to cut the time and costs associated with using such a complex hosts as production platforms. This book provides a comprehensive guide to the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity, improve cell function, glycosylation and secretion and control apoptosis. It presents an overall picture of the current topics central to expression engineering including such topics as epigenetics and the use of technologies to overcome positional dependent inactivation, the use of promoter and enhancer sequences for expression of various transgenes, site directed engineering of defined chromosomal sites, and examination of the role of eukaryotic nucleus as the controller of expression of genes that are introduced for production of a desired product. It includes a review of selection methods for high producers and an application developed by a major biopharmaceutical industry to expedite the cell line development process. The potential of cell engineering approch to enhance cell lines through the manipulation of single genes that play important roles in key metabolic and regulatory pathways is also explored throughout. |
| merck technology symposium 2023: Applied Reconfigurable Computing. Architectures, Tools, and Applications Francesca Palumbo, Georgios Keramidas, Nikolaos Voros, Pedro C. Diniz, 2023-09-15 This book constitutes the proceedings of the 19th International Symposium on Applied Reconfigurable Computing, ARC 2023, which was held in Cottbus, Germany, in September 2023. The 18 full papers presented in this volume were reviewed and selected from numerous submissions. The proceedings also contain 4 short PhD papers. The contributions were organized in topical sections as follows: Design methods and tools; applications; architectures; special session: near and in-memory computing; and PhD forum papers. |
| merck technology symposium 2023: 34th European Symposium on Computer Aided Process Engineering /15th International Symposium on Process Systems Engineering Flavio Manenti, G.V. Rex Reklaitis, 2024-06-27 The 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering, contains the papers presented at the 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering joint event. It is a valuable resource for chemical engineers, chemical process engineers, researchers in industry and academia, students, and consultants for chemical industries. - Presents findings and discussions from the 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering joint event |
| merck technology symposium 2023: Respiratory Drug Delivery (1989) Peter R. Byron, 2018-04-20 The focus of this book is on subjects related to drug delivery to the lung. The text spans topics from aerosol deposition through pharmaceutical chemistry and formulation to the final clinical evaluation of pharmaceutical products. Utilizing a multi-disciplinary approach, the chapters consider toxicology from the point of view of drugs and pharmaceutical excipients used in aerosols. |
| merck technology symposium 2023: Orphan Drugs and Rare Diseases David Pryde, Michael J Palmer, 2014-07-30 Orphan drugs are designated drug substances that are intended to treat rare or ‘orphan’ diseases. More than 7000 rare diseases are known that collectively affect some 6-7% of the developed world’s population; however, individually, any single, rare disease may only affect a handful of people making them commercially unattractive for the biopharmaceutical industry to target. Ground breaking legislation, starting with the Orphan Drug Act that was passed in the US in 1983 to provide financial incentives for companies to develop orphan drugs, has sparked ever increasing interest from biopharmaceutical companies to tackle rare diseases. These developments have made rare diseases, and the orphan drugs that treat them, sufficiently attractive to pharmaceutical development and many pharmaceutical companies now have research units dedicated to this area of research. It is therefore timely to review the area of orphan drugs and some of the basic science, drug discovery and regulatory factors that underpin this important, and growing, area of biomedical research. Written by a combination of academic and industry experts working in the field, this text brings together expert authors in the regulatory, drug development, genetics, biochemistry, patient advocacy group, medicinal chemistry and commercial domains to create a unique and timely reference for all biomedical researchers interested in finding out more about orphan drugs and the rare diseases they treat. Providing an up-to-date monograph, this book covers the basic science, drug discovery and regulatory elements behind orphan drugs and will appeal to medicinal and pharmaceutical chemists, biochemists and anyone working within the fields of rare disease research and drug development or pharmaceuticals in industry or academia. |
| merck technology symposium 2023: Bet the Farm Beth Hoffman, 2021-10-05 Eloquent and detailed...It's hard to have hope, but the organized observations and plans of Hoffman and people like her give me some. Read her book -- and listen. -- Jane Smiley, The Washington Post In her late 40s, Beth Hoffman decided to upend her comfortable life as a professor and journalist to move to her husband's family ranch in Iowa--all for the dream of becoming a farmer. There was just one problem: money. Half of America's two million farms made less than $300 in 2019, and many struggle just to stay afloat. Bet the Farm chronicles this struggle through Beth's eyes. She must contend with her father-in-law, who is reluctant to hand over control of the land. Growing oats is good for the environment but ends up being very bad for the wallet. And finding somewhere, in the midst of COVID-19, to slaughter grass finished beef is a nightmare. If Beth can't make it, how can farmers who confront racism, lack access to land, or don't have other jobs to fall back on hack it? Bet the Farm is a first-hand account of the perils of farming today and a personal exploration of more just and sustainable ways of producing food. |
| merck technology symposium 2023: Black Fatigue Mary-Frances Winters, 2020-09-15 This is the first book to define and explore Black fatigue, the intergenerational impact of systemic racism on the physical and psychological health of Black people—and explain why and how society needs to collectively do more to combat its pernicious effects. Black people, young and old, are fatigued, says award-winning diversity and inclusion leader Mary-Frances Winters. It is physically, mentally, and emotionally draining to continue to experience inequities and even atrocities, day after day, when justice is a God-given and legislated right. And it is exhausting to have to constantly explain this to white people, even—and especially—well-meaning white people, who fall prey to white fragility and too often are unwittingly complicit in upholding the very systems they say they want dismantled. This book, designed to illuminate the myriad dire consequences of “living while Black,” came at the urging of Winters's Black friends and colleagues. Winters describes how in every aspect of life—from economics to education, work, criminal justice, and, very importantly, health outcomes—for the most part, the trajectory for Black people is not improving. It is paradoxical that, with all the attention focused over the last fifty years on social justice and diversity and inclusion, little progress has been made in actualizing the vision of an equitable society. Black people are quite literally sickand tired of being sick and tired. Winters writes that “my hope for this book is that it will provide a comprehensive summary of the consequences of Black fatigue, and awaken activism in those who care about equity and justice—those who care that intergenerational fatigue is tearing at the very core of a whole race of people who are simply asking for what they deserve.” |
| merck technology symposium 2023: The Lean Approach to Digital Transformation Yves Caseau, 2022-05-01 The Lean Approach to Digital Transformation: From Customer to Code and From Code to Customer is organized into three parts that expose and develop the three capabilities that are essential for a successful digital transformation: 1. Understanding how to co-create digital services with users, whether they are customers or future customers. This ability combines observation, dialogue, and iterative experimentation. The approach proposed in this book is based on the Lean Startup approach, according to an extended vision that combines Design Thinking and Growth Hacking. Companies must become truly customer-centric, from observation and listening to co-development. The revolution of the digital age of the 21st century is that customer orientation is more imperative -- the era of abundance, usages rate of change, complexity of experiences, and shift of power towards communities -- are easier, using digital tools and digital communities. 2. Developing an information system (IS) that is the backbone of the digital transformation – called “exponential information system” to designate an open IS (in particular on its borders), capable of interfacing and combining with external services, positioned as a player in software ecosystems and built for processing scalable and dynamic data flows. The exponential information system is constantly changing and it continuously absorbs the best of information processing technology, such as Artificial Intelligence and Machine Learning. 3. Building software “micro-factories” that produce service platforms, which are called “Lean software factories.” This “software factory” concept covers the integration of agile methods, tooling and continuous integration and deployment practices, a customer-oriented product approach, and a platform approach based on modularity, as well as API-based architecture and openness to external stakeholders. This software micro-factory is the foundation that continuously produces and provides constantly evolving services. These three capabilities are not unique or specific to this book, they are linked to other concepts such as agile methods, product development according to lean principles, software production approaches such as CICD (continuous integration and deployment) or DevOps. This book weaves a common frame of reference for all these approaches to derive more value from the digital transformation and to facilitate its implementation. The title of the book refers to the “lean approach to digital transformation” because the two underlying frameworks, Lean Startup and Lean Software Factory, are directly inspired by Lean, in the sense of the Toyota Way. The Lean approach is present from the beginning to the end of this book -- it provides the framework for customer orientation and the love of a job well done, which are the conditions for the success of a digital transformation. |
| merck technology symposium 2023: Equine Welfare in Clinical Practice Virginia Wensley Koch, 2024-08-29 Equine Welfare in Clinical Practice: How and Why Behavior and Welfare Assessments Belong in Your Practice reviews the current psychological, behavioral, and welfare knowledge equine veterinarians should have and discusses how such knowledge may be incorporated into clinical practices. It covers such topics as practical welfare assessment, fear-free practices, and how horses learn (both good and bad habits). Each topic is intended to provide both practical and pertinent science-based information for equine practitioners and their clients. Written by international experts, this book explores the physical, psychological, and behavioral factors contributing to equine welfare. It discusses current knowledge about topics such as equine senses, cognition, and stereotypies, as well as appropriate and inappropriate training methods, for both adult horses and foals. It also addresses differentiating medical from behavioral problems and discusses the new field of how the gut microbiome affects behavior. Equine Welfare in Clinical Practice: How and Why Behavior and Welfare Assessments Belong in Your Practice is an important resource for clinical veterinarians who want to incorporate knowledge of equine behavior and welfare into their practices. Veterinarians who understand and can educate their clients in equine welfare and safe and appropriate care and handling techniques will increase their business success, improve the lives of their clients and patients, and strengthen the human-animal bond. In addition, the book will also provide updated information and useful practical tips for those who are already familiar with equine psychology, behavior, and welfare. - Emphasizes the clinical applications of the sciences of equine behavior and welfare - Offers expert recommendations to improve the lives of horses, their owners, and the veterinarians who care for them - Provides resources for further study and access to specialists for consultation or referral |
| merck technology symposium 2023: Plumb's Veterinary Drug Handbook Donald C. Plumb, 2018-02-21 Plumb’s Veterinary Drug Handbook, Ninth Edition updates the most complete, detailed, and trusted source of drug information relevant to veterinary medicine. Provides a fully updated edition of the classic veterinary drug handbook, with carefully curated dosages per indication for clear guidance on selecting a dose Features 16 new drugs Offers an authoritative, complete reference for detailed information about animal medication Designed to be used every day in the fast-paced veterinary setting Includes dosages for a wide range of species, including dogs, cats, exotic animals, and farm animals |
| merck technology symposium 2023: U.S. Environmental Protection Agency Library System Book Catalog Holdings as of July 1973 United States. Environmental Protection Agency. Library Systems Branch, 1974 |
| merck technology symposium 2023: Antibody Engineering J. Donald Capra, 1997 The last decade has witnessed remarkable developments in antibody research and its therapeutic applications. With the methods of molecular biology it is now possible to manipulate the specificities and activities of antibody molecules to generate an almost limitless array of structures for both basic investigations and the clinical setting. The contributions to this volume cover all three domains of the antibody: the variable regions, the relatively neglected but crucial hinge, and the constant region. These studies provide critical structural and functional information about antibodies, while also pointing the way to the construction of molecules with enhanced or even novel properties. Bringing together major experts on antibody engineering, this book is highly recommended to faculty, postdoctoral fellows and graduate students in molecular biology, microbiology, immunology, cancer research and genetics. |
| merck technology symposium 2023: Fault Detection and Diagnosis in Industrial Systems L.H. Chiang, E.L. Russell, R.D. Braatz, 2012-12-06 Early and accurate fault detection and diagnosis for modern chemical plants can minimize downtime, increase the safety of plant operations, and reduce manufacturing costs. This book presents the theoretical background and practical techniques for data-driven process monitoring. It demonstrates the application of all the data-driven process monitoring techniques to the Tennessee Eastman plant simulator, and looks at the strengths and weaknesses of each approach in detail. A plant simulator and problems allow readers to apply process monitoring techniques. |
| merck technology symposium 2023: Chemistry and Industry , 2009 |
| merck technology symposium 2023: Drug Discovery and Development, Third Edition James J. O'Donnell, John Somberg, Vincent Idemyor, James T. O'Donnell, 2019-12-13 Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business |
| merck technology symposium 2023: Gnotobiotics Trenton R Schoeb, Kathryn A Eaton, 2017-08-11 Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource. - Reviews and defines gnotobiotic animal species - Analyzes microbiota in numerous contexts - Presents detailed coverage of the protocols and operation of a gnotobiotic facility |
| merck technology symposium 2023: Cancer Immunotherapy Principles and Practice Lisa H. Butterfield, Howard L. Kaufman, Francesco M. Marincola, 2017 Part 1: Intratumoral Signatures Associated With Immune Responsiveness |
| merck technology symposium 2023: Causality, Probability, and Time Samantha Kleinberg, 2013 Presents a new approach to causal inference and explanation, addressing both the timing and complexity of relationships. |
| merck technology symposium 2023: The Fifth Trimester Lauren Smith Brody, 2017-04-04 Packed with honest, funny, and comforting advice—“a book you MUST read if you are returning to work after the birth of a child…. I loved it and you will too.” —New York Times bestselling author Lois P. Frankel, Ph.D. The first three trimesters (and the fourth—those blurry newborn days) are for the baby, but the Fifth Trimester is when the working mom is born. A funny, tells-it-like-it-is guide for new mothers coping with the demands of returning to the real world after giving birth, The Fifth Trimester contains advice from 800 moms, including: •The boss-approved way to ask for flextime (and more money!) •How to know if it’s more than “just the baby blues” •How to pump breastmilk on an airplane (or, if you must, in a bathroom) •What military science knows about working through sleep deprivation •Your new sixty-second get-out-of-the-house beauty routine •How to turn your commute into a mini–therapy session •Your daycare tour or nanny interview, totally decoded |
| merck technology symposium 2023: The History of Cyclodextrins Grégorio Crini, Sophie Fourmentin, Eric Lichtfouse, 2020-09-29 This book presents the historical development of Cyclodextrins by scientists who have made outstanding contribution to the field. Cyclodextrins are safe, cage-like molecules that have found major applications in many industrial sectors such as medicine, food, agriculture, environment and chemistry. |
| merck technology symposium 2023: The Impact Investor Cathy Clark, Jed Emerson, Ben Thornley, 2014-09-22 Your money can change the world The Impact Investor: Lessons in Leadership and Strategy for Collaborative Capitalism offers precise details on what, exactly, impact investing entails, embodied in the experiences and best and proven practices of some of the world's most successful impact investors, across asset classes, geographies and areas of impact. The book discusses the parameters of impact investing in unprecedented detail and clarity, providing both context and tools to those eager to engage in the generational shift in the way finance and business is being approached in the new era of Collaborative Capitalism. The book presents a simple thesis with clarity and conviction: Impact investing can be done successfully. This is what success looks like, and this is what it requires. With much-needed lessons for practitioners, the authors view impact investing as a harbinger of a new, more multilingual (cross-sector), transparent, and accountable form of economic leadership. The Impact Investor: Lessons in Leadership and Strategy for Collaborative Capitalism serves as a resource for a variety of players in finance and business, including: Investors: It demonstrates not only the types of investments which can be profitable and impactful, but also details best practices that, with roots in impact investing, will increasingly play a role in undergirding the success of all investment strategies. Wealth advisors/financial services professionals: With unprecedented detail on the innovative structures and strategies of impact investing funds, the book provides guidance to financial institutions on how to incorporate these investments in client portfolios. Foundations: The book explores the many catalytic and innovative ways for for-profit and non-profit investors to partner, amplifying the potential social and environmental impacts of philanthropic spending and market-rate endowment investment. Business students: By including strategies for making sound impact investments based on detailed case studies, it provides concrete lessons and explores the skills required to enhance prospects for success as a finance and business professional. Policy makers: Reinforcing the urgency of creating a supportive and enabling environment for impact investing, the book demonstrates ways policy has already shaped the sector, and suggests new ways for policymakers to support it. Corporate leaders: The book includes essential advice on the way business is and must be responding to a new generation of Millennial clients and customers, with unique insights into a form of value creation that is inherently more collaborative and outcomes-driven. |
| merck technology symposium 2023: Digital Pathology Liron Pantanowitz, Anil V. Parwani, 2017 The definitive, complete reference of digital pathology! An extraordinarily comprehensive and complete book for individuals with anything from minimal knowledge to deep, accomplished experience in digital pathology. Easy to read and plainly written, Digital Pathology examines the history and technological evolution of digital pathology, from the birth of scanning technology and telepathology to three-dimensional imaging on large multi-touch displays and computer aided diagnosis. A must-have book for anyone wishing to learn more about and work in this exciting and critical information environment including pathologists, laboratory professionals, students and any other medical practitioners with a particular interest in the history and future of digital pathology. It can also be a useful reference for anyone, medical or non-medical, who have an interest in learning more about the field. Digital pathology is truly a game changer, and this book is a crucial tool for anyone wishing to know more. Subjects discussed in depth include: Static digital imaging; basics and clinical use. Digital imaging processes. Telepathology. While slide imaging. Clinical applications of whole slide imaging. Digital pathology for educational, quality improvement, research and other settings. Forensic digital imaging. |
| merck technology symposium 2023: Continuous Biomanufacturing Ganapathy Subramanian, 2017-12-26 This is the most comprehensive treatise of this topic available, providing invaluable information on the technological and economic benefits to be gained from implementing continuous processes in the biopharmaceutical industry. Top experts from industry and academia cover the latest technical developments in the field, describing the use of single-use technologies alongside perfusion production platforms and downstream operations. Special emphasis is given to process control and monitoring, including such topics as 'quality by design' and automation. The book is supplemented by case studies that highlight the enormous potential of continuous manufacturing for biopharmaceutical production facilities. |
| merck technology symposium 2023: Cell and Gene Therapies Miguel-Angel Perales, Syed A. Abutalib, Catherine Bollard, 2018-11-27 In this book, experts in the field express their well-reasoned opinions on a range of complex, clinically relevant issues across the full spectrum of cell and gene therapies with the aim of providing trainee and practicing hematologists, including hematopoietic transplant physicians, with information that is relevant to clinical practice and ongoing research. Each chapter focuses on a particular topic, and the concise text is supported by numerous working tables, algorithms, and figures. Whenever appropriate, guidance is provided regarding the availability of potentially high-impact clinical trials. The rapid evolution of cell and gene therapies is giving rise to numerous controversies that need to be carefully addressed. In meeting this challenge, this book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients. It will also offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee. |
| merck technology symposium 2023: Materials for a Sustainable Future Trevor M. Letcher, Janet L. Scott (Chemist), 2012 Aimed at students, lecturers, researchers, and policy makers, this work describes current developments and points the way forward for new developments regarding materials in our society and how they relate to sustainability. |
| merck technology symposium 2023: 16th Deep-Sea Biology Symposium Alexandra Anh-Thu Weber, Eleonora Puccinelli, Paris Vasileios Stefanoudis, Daniela Zeppilli, 2023-11-28 The 16th Deep-Sea Biology Symposium was held in Brest, France, and online from the 12th to the 17th of September 2021. The first DSBS hybrid symposium brought together scientists, students, managers, policymakers, and industry specialists who presented advances in deep-sea research. Themes of the symposium, and of this Research Topic, include: - Conservation and stewardship: natural/anthropogenic impacts, conservation, governance. This includes but it is not limited to: deep-seabed mining, pollutants and debris, climate change impacts; marine spatial planning; stewardship of the deep ocean; - Biodiversity and ecosystem functioning: biodiversity patterns, species distribution, function; from polar to temperate regions, mesopelagic to hadal, microbes to large pelagic; - Life-history traits and population connectivity: reproductive ecology, larval development and dispersal, and population connectivity; - Adaptations of deep-sea organisms: from molecules to organisms: how life adapts to extreme conditions, including for instance bioluminescence and vision in the deep-sea; - Access to the deep sea: technological and methodological advances to access and investigate deep-sea life, including observatories and cutting edge technologies –e.g. A.I. and omics; - Deep-sea biomimicry: discovery of new technologies inspired by deep-sea biological solutions; - Science communication in the deep including innovative approaches to increase ocean literacy (merging “arts & sciences”). |
| merck technology symposium 2023: blogdown Yihui Xie, Alison Presmanes Hill, Amber Thomas, 2017-12-01 blogdown: Creating Websites with R Markdown provides a practical guide for creating websites using the blogdown package in R. In this book, we show you how to use dynamic R Markdown documents to build static websites featuring R code (or other programming languages) with automatically rendered output such as graphics, tables, analysis results, and HTML widgets. The blogdown package is also suitable for technical writing with elements such as citations, footnotes, and LaTeX math. This makes blogdown an ideal platform for any website designed to communicate information about data science, data analysis, data visualization, or R programming. Note that blogdown is not just for blogging or sites about R; it can also be used to create general-purpose websites. By default, blogdown uses Hugo, a popular open-source static website generator, which provides a fast and flexible way to build your site content to be shared online. Other website generators like Jekyll and Hexo are also supported. In this book, you will learn how to: Build a website using the blogdown package; Create blog posts and other website content as dynamic documents that can be easily edited and updated; Customize Hugo templates to suit your site’s needs; Publish your website online; Migrate your existing websites to blogdown and Hugo. |
| merck technology symposium 2023: Natural Product Biosynthesis Christopher T. Walsh, Yi Tang, 2017-04-28 This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. |
| merck technology symposium 2023: Healthcare Digital Transformation Edward W. Marx, Paddy Padmanabhan, 2020-08-02 This book is a reference guide for healthcare executives and technology providers involved in the ongoing digital transformation of the healthcare sector. The book focuses specifically on the challenges and opportunities for health systems in their journey toward a digital future. It draws from proprietary research and public information, along with interviews with over one hundred and fifty executives in leading health systems such as Cleveland Clinic, Partners, Mayo, Kaiser, and Intermountain as well as numerous technology and retail providers. The authors explore the important role of technology and that of EHR systems, digital health innovators, and big tech firms in the ongoing digital transformation of healthcare. Importantly, the book draws on the accelerated learnings of the healthcare sector during the COVID-19 pandemic in their digital transformation efforts to adopt telehealth and virtual care models. Features of this book: Provides an understanding of the current state of digital transformation and the factors influencing the ongoing transformation of the healthcare sector. Includes interviews with executives from leading health systems. Describes the important role of emerging technologies; EHR systems, digital health innovators, and more. Includes case studies from innovative health organizations. Provides a set of templates and frameworks for developing and implementing a digital roadmap. Based on best practices from real-life examples, the book is a guidebook that provides a set of templates and frameworks for digital transformation practitioners in healthcare. |
| merck technology symposium 2023: The Breakthrough Charles Graeber, 2015-12-01 Follow along as this New York Times bestselling author details the astonishing scientific discovery of the code to unleashing the human immune system to fight in this captivating and heartbreaking book (The Wall Street Journal). For decades, scientists have puzzled over one of medicine's most confounding mysteries: Why doesn't our immune system recognize and fight cancer the way it does other diseases, like the common cold? As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses -- tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer's penicillin moment, a revolutionary discovery in our understanding of cancer and how to beat it. In The Breakthrough, New York Times bestselling author of The Good Nurse Charles Graeber guides readers through the revolutionary scientific research bringing immunotherapy out of the realm of the miraculous and into the forefront of twenty-first-century medical science. As advances in the fields of cancer research and the human immune system continue to fuel a therapeutic arms race among biotech and pharmaceutical research centers around the world, the next step -- harnessing the wealth of new information to create modern and more effective patient therapies -- is unfolding at an unprecedented pace, rapidly redefining our relationship with this all-too-human disease. Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history. |
| merck technology symposium 2023: Reactive Inkjet Printing Patrick J Smith, Aoife Morrin, 2017-11-27 Reactive inkjet printing uses an inkjet printer to dispense one or more reactants onto a substrate to generate a physical or chemical reaction to form a product in situ. Thus, unlike traditional inkjet printing, the printed film chemistry differs to that of the initial ink droplets. The appeal of reactive inkjet printing as a chemical synthesis tool is linked to its ability to produce droplets whose size is both controllable and predictable, which means that the individual droplets can be thought of as building blocks where droplets can be added to the substrate in a high precision format to give good control and predictability over the chemical reaction. The book starts by introducing the concept of using reactive inkjet printing as a building block for making materials. Aspects such as the behaviour of printed droplets on substrate and their mixing is discussed in the first chapters. The following chapters then discuss different applications of the technique in areas including additive manufacturing and silk production, production of materials used in solar cells, printed electronics, dentistry and tissue engineering. Edited by two leading experts, Reactive Inkjet Printing: A Chemical Synthesis Tool provides a comprehensive overview of this technique and its use in fabricating functional materials for health and energy applications. The book will appeal to advanced level students in materials science. |
| merck technology symposium 2023: Chemotherapy and Immunotherapy Guidelines and Recommendations for Practice MiKaela M. Olsen, Kristine B. LeFebvre, Suzanne L. Walker, Elizabeth Prechtel Dunphy, 2022 Oncology nursing is a unique specialty that requires continuous learning to stay up to date on cancer pathophysiology, cutting-edge drugs, and the evidence-based management of cancer and cancer treatment-related toxicities. The Oncology Nursing Society's (ONS's) second edition of Chemotherapy and Immunotherapy Guidelines and Recommendations for Practice provides nurses with the tools to understand how medications are used in cancer treatment, the effect of medication-related toxicities, and evidence-based recommendations to manage and treat these toxicities. This edition features many new cancer therapies approved since the 2019 publication. Each drug is categorized as chemotherapy, hormone, targeted, or immunotherapy agents. Extensive drug tables in the book provide nurses with tips for managing patients receiving these drugs. The expansion of oral antineoplastic therapies, alone or in combination with infusion therapy, requires that nurses review a patient's complete cancer treatment plan and consider the side effects, toxicities, and adherence to oral drugs to ensure patient tolerance and efficacy. This second edition has seen content expanded on the topic of genomics as we move forward in the world of personalized oncology. Health equity is approached with information discussing financial distress, cultural disparities, and health literacy. The latest guidelines and recommendations for treatment, symptom management, and survivorship have been integrated into this new text. This edition features a QR code, provided with the purchase of this book, to download quarterly drug updates. You will see new evidence related to many aspects of cancer nursing care incorporated into this edition, such as hypersensitivity response, safe handling of hazardous drugs, and more. The editors want to thank all of the contributors to this edition who worked tirelessly, despite a pandemic, to make this new edition a reality. This work builds on the knowledge of many generations of oncology nurses and has been used nationally and internationally to guide oncology nursing practice. We are proud to continue to serve oncology nurses worldwide with an essential resource to guide their practice-- |
| merck technology symposium 2023: Thankful Thursdays Nicholas Kartsonis, 2019-11-26 This version includes color photos.Can you imagine waking up every Thursday morning to an engaging email containing an essay of gratitude? Better yet, could you envision finding this thank you note coming from your boss? For a year, Nicholas Kartsonis took his direct reports on a fascinating odyssey exploring a variety of topics. Most essays show gratitude for the wonders of modern science, with a focus on medical discoveries in infectious disease, vaccinology, and microbiology that have changed the course of humanity. Along the way, Nick also shares his appreciation for people, places, and events that have personally touched him in his own journey as a physician, a father, and a sports fan. He chose the timing of each essay to correspond to an important event in history, and uses this association to recount the significance of each achievement. This book showcases Nick's favorite stories, each showing the positive side of a world often dominated by negativity, mistrust, and skepticism. |
| merck technology symposium 2023: Biocontamination Control for Pharmaceuticals and Healthcare Tim Sandle, 2024-01-28 Biocontamination Control for Pharmaceuticals and Healthcare outlines a biocontamination strategy that tracks bio-burden control and reduction at each transition in classified areas of a facility. The first edition of the book covered many of the aspects of the strategy, but the new official guidance signals that a roadmap is required to fully comply with its requirements. Completely updated with the newest version of the EU-GPM (EN17141) the new edition expands the coverage of quality risk management and new complete examples to help professionals bridge the gap between regulation and implementation. Biocontamination Control for Pharmaceuticals and Healthcare offers professionals in pharma quality control and related areas guidance on building a complete biocontamination strategy. - Includes the most current regulations - Contains three new chapters, including Application of Quality Risk Management and its Application in Biocontamination Control, Designing an Environmental Monitoring Programme, and Synthesis: An Anatomy of a Contamination Control Strategy - Offers practical guidance on building a complete biocontamination strategy |
| merck technology symposium 2023: The Ownership of Enterprise Henry Hansmann, 2009-07-01 The investor-owned corporation is the conventional form for structuring large-scale enterprise in market economies. But it is not the only one. Even in the United States, noncapitalist firms play a vital role in many sectors. Employee-owned firms have long been prominent in the service professions--law, accounting, investment banking, medicine--and are becoming increasingly important in other industries. The buyout of United Airlines by its employees is the most conspicuous recent instance. Farmer-owned produce cooperatives dominate the market for most basic agricultural commodities. Consumer-owned utilities provide electricity to one out of eight households. Key firms such as MasterCard, Associated Press, and Ace Hardware are service and supply cooperatives owned by local businesses. Occupant-owned condominiums and cooperatives are rapidly displacing investor-owned rental housing. Mutual companies owned by their policyholders sell half of all life insurance and one-quarter of all property and liability insurance. And nonprofit firms, which have no owners at all, account for 90 percent of all nongovernmental schools and colleges, two-thirds of all hospitals, half of all day-care centers, and one-quarter of all nursing homes. Henry Hansmann explores the reasons for this diverse pattern of ownership. He explains why different industries and different national economies exhibit different distributions of ownership forms. The key to the success of a particular form, he shows, depends on the balance between the costs of contracting in the market and the costs of ownership. And he examines how this balance is affected by history and by the legal and regulatory framework within which firms are organized. With noncapitalist firms now playing an expanding role in the former socialist countries of Eastern Europe and Asia as well as in the developed market economies of the West, The Ownership of Enterprise will be an important book for business people, policymakers, and scholars. |
| merck technology symposium 2023: Indigenizing the Academy Devon Abbott Mihesuah, Angela Cavender Wilson, 2004-01-01 Native American scholars reflect on issues related to academic study by students drawn from the indigenous peoples of America. Topics range from problems of racism and ethnic fraud in academic hiring to how indigenous values and perspectives can be integrated into research methodologies and interpretive theories. |
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At Merck, we're following the science to tackle some of the world's greatest health threats. Get a glimpse of how we work to improve lives.
Company fact sheet - Merck.com
Dec 31, 2024 · Merck is a global health care company that delivers innovative health solutions through its prescription medicines, vaccines, biologic therapies, and animal …
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Merck aspires to be the premier research-intensive biopharmaceutical company in the world. Learn about our commitment to save and improve lives.
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Learn how Merck has created a legacy of inventing medicines and vaccines and become a leading global biopharmaceutical company over the past 130 years.
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Merck | Home
At Merck, we're following the science to tackle some of the world's greatest health threats. Get a glimpse of how we work to improve lives.
Company fact sheet - Merck.com
Dec 31, 2024 · Merck is a global health care company that delivers innovative health solutions through its prescription medicines, vaccines, biologic therapies, and animal health products. …
Who we are - Merck.com
Merck aspires to be the premier research-intensive biopharmaceutical company in the world. Learn about our commitment to save and improve lives.
History - Merck.com
Learn how Merck has created a legacy of inventing medicines and vaccines and become a leading global biopharmaceutical company over the past 130 years.
Discover Job Opportunities at Merck | Merck Careers
Explore current job opportunities at Merck. Learn more about careers in Business Support, Clinical, Engineering, Information Technology, Research & Development, Manufacturing and …
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Merck aspires to be the premier research-intensive biopharmaceutical company in the world. Learn about our commitment to save and improve lives.
Merck Announces First-Quarter 2025 Financial Results
Apr 24, 2025 · Merck continues to expect full-year 2025 sales to be between $64.1 billion and $65.6 billion, including a revised negative impact of foreign exchange of approximately 1% at …
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Merck Breaks Ground on New $1 Billion Biologics Center of …
Apr 29, 2025 · A cornerstone of Merck’s continued commitment to investing in American innovation and infrastructure, Merck Wilmington Biotech will comprise laboratory, …
Our Q4 and full-year 2024 financial results - Merck.com
Merck’s Q4 and full-year 2024 results reflect strong growth. Our company announced Q4 worldwide sales of $15.6 billion, an increase of 7% from Q4 2023. Full-year 2024 worldwide …
